Most Vette owners I know hate their run flat tires. I'd say that is the thing changed most on Vettes is ditching the run flats. Read some reviews for Corvettes on tirerack. There are many reviews from Vette owners raving about their new non-run flat tires. They are loud, they are stiff, and handling with them is garbage. If you have speed rated tires, the tire isn't going to just give up on you at high speed if you are taking care of it and keeping it properly inflated. Remember, the #1 cause of tire failure is improper inflation. Its only going to fail if you hit something and if you hit something to blow a tire at speed, the blown tire problaby isn't your only problem.
I have 245/45/17's on the front of mine. I felt that was way too short for the back (especially with 4.10's) and the back has 255/45/18's. This tire fills the wheel well perfectly and if I had it to do over I would problaby put them on all 4 corners although I like the look of it the way it is.
Former owner of 94 Bird with DOHC 4.6L swapped from a mark VIII
2011 CTS-V Wagon
1968 Torino was an original 289, C4, fully documented numbers matching car. Now: DOHC 4.6L/T-56 swapped, Cobra intake, IMRC delete, BBK long tubes and H pipe. Dynotech Aluminum Driveshaft, 9" rear with TrueTrac and 4.11's.