That makes total sense about the waste spark system and tracking down a misfire. The easiest way is to take a test light and probe each boot (creating a short which prevents that cylinder from firing).
Picture is worth a thousand words, thanks ..
Although a couple things I do not recommend:
Un-plugging plug wires and running engine can put excess fuel into the cylinder chamber creating potential for catalytic converter damage, cylinder washing and pre-ignition.
Piercing insulation on plug wires can create secondary leakage, the Arc could possibly travel out of the boot later and cause a misfire that wasnt there before. Its an easy test, much like spraying your engine with water in the dark to see if arcing is present at the wires. A spark plug tester is probably the most cost effective way to go about testing without having more expensive equipment.
Scope analysis is the best way although most people here dont own or have access to a graphing multimeter, KV module, digital oscilloscope, etc. But if you know the KV voltage is excessive, you have high resistance in the plug wires or the spark gap is too large, too much air / not enough fuel (lean mixture). Lower KV voltage readings inducate a short to ground, secondary leakage or a weak coil.
Most people just shotgun it and replace the plugs / wires since most of the time its not the coil itself.